Predicting 6-9 months engagement index based on the 3-6 months engagement index.
To predict the EI of patients with cancer between 6 and 9 months based on their EI between 3 and 6 months, we excluded the initial 0- to 3-month period as the patients were actively under hospital surveillance with ongoing follow-ups. For the existing EI, we observed a mean squared error (MSE) of 0.096, root mean squared error (RMSE) of 0.310, and R 2 of 0.053. For the new EI, we conducted 3 multiple linear regressions to identify the most significant menu combinations. The first combination (new EI1), comprising meal log, exercise log, message sent to the app, reading content, and weight log, exhibited an MSE of 0.036, RMSE of 0.190, and R 2 of 0.511. The second combination (new EI2), involving meal log, exercise log, weight log, and step count login, showed improved performance with an MSE of 0.025, RMSE of 0.157, and R 2 of 0.610. The third combination (new EI3), encompassing meal log, exercise log, message sent to the app, reading content, weight log, and step count login, yielded an MSE of 0.042, RMSE of 0.205, and R 2 of 0.374. The values of the multiple linear regression are presented in Table 2 .
MSE | RMSE | ||
Existing EI | 0.096 | 0.310 | 0.053 |
New EI1 | 0.036 | 0.190 | 0.511 |
New EI2 | 0.025 | 0.157 | 0.610 |
New EI3 | 0.042 | 0.205 | 0.374 |
a MSE: mean squared error.
b RMSE: root mean squared error.
c EI: engagement index.
When predicting app usage survival using the individual index of the EI from 3 to 6 months through Cox regression, the existing EI exhibited a log rank test result of P <.05. The results indicated a significant association between click depth and loyalty indices, while the RI showed no significance. The click depth index exhibited an HR of 0.49 with a P value <.001, which indicates that a higher click depth index is significantly associated with the reduced hazard, thus yielding better outcomes. Similarly, the LI showed an HR of 0.17 and a P value <.001, demonstrating a strong and significant association with reduced hazard. Conversely, the RI showed an HR of 1.30 with a P value of .41, indicating no significant association. All the log rank test results were statistically significant. The values of the existing EI are presented in Table 3 .
HR (95% CI) | value | |
Click depth index | 0.49 (0.29-0.84) | <.001 |
Loyalty index | 0.17 (0.09-0.31) | <.001 |
Recency index | 1.30 (1.70-2.42) | .41 |
a HR: hazard ratio.
For the new EI, we conducted 3 Cox regressions based on the three devised menu combinations. MI 1 incorporates the menus intended for active app users, encompassing those necessitating self-logging. It specifically encompasses meal log, exercise log, messages sent to the app, reading content, and weight log. MI 2 comprises menus available in the app’s free version. It consists of a meal log, exercise log, weight log, and step count login. MI 3 includes all available menus, such as meal log, exercise log, message sent to the app, reading content, weight log, and step count login. Hence, 3 new EIs were created (new EI1, new EI2, and new EI3), which includes each MI (MI1, MI2, and MI3).
New EI1 exhibited no significant association with the MI (HR 0.92; P =.81). However, it showed a strong and significant association with the LI (HR 0.28; P <.001). Furthermore, it showed a significant association with the RI (HR 0.48). Meanwhile, new EI2 exhibited a similar trend to new EI1, showing no significant association with the MI (HR 0.79; P =.50). However, it showed a strong and significant association with the LI (HR 0.3). Moreover, it exhibited a significant association with the RI (HR 0.47). Finally, new EI3 showed no significant association with the MI (HR 0.95; P =.82). However, it showed a significant and strong association with the LI (HR 0.26; P <.001), but it did not exhibit a significant association with the RI (HR 0.74; P =.23).
The MI did not exhibit a significant association with any of the new indices, whereas the LI showed a strong and significant association with all 3 indices. The RI was significantly associated with new EI1 and new EI2 but not with new EI3. All the log rank test results were significant for all the new indices. The values of the new EI are presented in Table 4 .
New EI1 | New EI2 | New EI3 | ||
HR (95% CI) | 0.92 (0.48-1.77) | 0.79 (0.40-1.56) | 0.95 (0.57-1.58) | |
value | .81 | .50 | .82 | |
HR (95% CI) | 0.28 (0.14-0.54) | 0.31 (0.16-0.62) | 0.26 (0.15-.46) | |
value | <.001 | <.001 | <.001 | |
HR (95% CI) | 0.48 (0.28-0.81) | 0.47 (0.30-0.75) | 0.74 (0.45-1.22) | |
value | <.001 | <.001 | .23 |
We evaluated the existing EI in a commercial health management app for long-term use and compared it with the new EI. We evaluated the new EI by first predicting the EI of the 6- to 9-month period based on the EI of the 3- to 6-month period through multiple linear regression and by predicting the survival rate using the EI of the 3- to 6-month period. In both predictions, the new EI exhibited better performance than the existing EI, although the difference was marginal. Moreover, when the RI, the index that best represents the long-term use, was applied in the new EI, a statistically significant difference increased compared with the RI in the existing EI.
Retention has been inconsistently measured across studies in the aspect of mHealth. For instance, a previous study [ 25 ] defined retention as continuous use of the app for 6 months after the first use, specifically between 150 and 210 days. Another study measured retention based solely on the number of logs [ 26 ]. In addition, 1 study [ 27 ] measured retention through follow-up interviews conducted 6 months post intervention. These variations highlight the lack of a standardized retention strategy in mHealth research, posing a significant limitation as results may hinge on a single participant’s interview response rather than reflecting overall trends and maintained use.
While the use of mHealth has the potential to enhance adherence to chronic disease management, research predominantly focuses on the assessment of the usability, feasibility, and acceptability of such apps rather than the direct measurement of adherence [ 28 ]. Similarly, studies addressing patient engagement in mHealth interventions in heart failure cases are often underreported and lacking consistency [ 29 ]. Moreover, a pressing need to evaluate user engagement in smartphone apps targeting other significant risk factors for cardiovascular disease, such as dietary behaviors, has been emphasized. Yang et al [ 30 ] identified 3 key issues concerning the measurement of adherence in mHealth programs. These include challenges in defining and measuring adherence, a tendency for adherence measurements to be grounded in empirical evidence or established theory, and the recognition that adherence is a multifaceted concept, thus requiring a comprehensive assessment rather than reliance on a 1-dimensional approach [ 30 ].
Although existing methodologies for measuring adherence to mHealth are limited, fewer measures of adherence with numerical results. Therefore, measurement using the EI has been considered a methodology that could be generally used and numerically measured. Taki et al [ 31 ] conducted a study that used the EI to measure engagement in the mHealth app. They used the click depth, loyalty, interaction, recency, and feedback indices and categorized the results into 3 groups to observe changes in the EI over time. However, they noted that some features were not measured by the EI, which may result in the underestimation of engagement of the participants. Similarly, White et al [ 32 ] used the EI to examine the demographic differences among 3 groups formed by the EI and used the reading, loyalty, interaction, recency, and feedback indices. However, they were unable to detect an association between the level of engagement and the duration of exclusive breastfeeding, which was possibly due to the limitations of the EI. Furthermore, Schepens Niemiec et al [ 33 ] used the loyalty, interaction, usability, and sentiment feedback indices with semistructured interviews to measure app engagement. They acknowledged that as only 4 indices were used, the statistical norm could not be determined to validate the evaluation of the mHealth apps. Despite its applicability to various programs offered by mHealth apps, EI exhibited similar limitations in each study, thereby raising uncertainties regarding its implications. However, despite the thorough investigation, with its simple characteristics, EI can effectively measure engagement in mHealth apps.
Reliance on postintervention surveys or interviews was common in other previous studies evaluating DTx engagement [ 10 - 14 ]. Alternatively, engagement with DTx was occasionally assessed simplistically, such as by marking the first date of a 28-day period without any data upload or by calculating the percentage of participants who completed follow-up at 8 weeks [ 34 , 35 ]. A review of various literature revealed that a more objective measure was evidently needed to evaluate patient engagement in DTx. Although valuable, manual interviews are difficult to replicate and are time consuming due to their labor-intensive nature, involving multiple coordinators. Therefore, the proposal and evaluation of an EI for DTx could enhance the quality of research in this field.
This study represents the inaugural attempt to evaluate the existing EI. While the effectiveness of the index has not yet been evaluated, we have established its reliability despite the comprehensive evaluation for potential upgrades. Furthermore, we were able to demonstrate the importance of log data from a research viewpoint as well as its objectivity, reproducibility, and potential for use to evaluate adherence to mHealth.
EI has a subjective nature in the metrics that may potentially introduce biases, which cannot be overcome despite the update of the index. Furthermore, although the existing EI comprises 7 indices, this evaluation focused only on 3 indices due to the specific characteristics of the app under scrutiny. Also, while the results may indicate that the newly developed EI outperforms the existing EI, the calculation of the existing EI may be simpler than the newly developed EI. However, we believe that this approach is more effective in predicting and representing long-term use.
This study evaluated the new EI within the commercial health management app by comparing it with the existing EI. Despite thorough evaluation using 2 approaches (forecasting the EI of the 6- to 9-month period based on the EI of the 3- to 6-month period through multiple linear regression and predicting survival rates based on the EI of the 3- to 6-month period), the new EI exhibited a slightly superior performance to the existing EI in both approaches. Although the existing EI appeared too simplistic for evaluating mHealth app adherence, we were able to demonstrate that it effectively reflected adherence without the need for complex calculations, similar to the new EI.
This research was supported by a grant from the Korea Health Technology R and D Project through the Korea Health Industry Development Institute and funded by the Ministry of Health & Welfare, Republic of Korea (grant HI20C1058).
The data sets generated or analyzed during this study are not publicly available due to the need for institutional review board approval and privacy considerations but are available from the corresponding author upon reasonable request.
All authors contributed to the conceptualization and reviewing and editing. YWT, JK, and YL handled the formal analysis. YWT, JK, and YL contributed to writing the original draft. JWL managed the resources.
None declared.
digital therapeutics |
engagement index |
hazard ratio |
loyalty index |
mobile health |
menu abundancy index |
mean squared error |
permutation entropy |
randomized controlled trial |
recency index |
root mean squared error |
Edited by G Eysenbach, T de Azevedo Cardoso; submitted 12.04.24; peer-reviewed by A Wani, D Ghosh; comments to author 09.05.24; revised version received 02.07.24; accepted 30.07.24; published 09.09.24.
©Yae Won Tak, Jong Won Lee, Junetae Kim, Yura Lee. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 09.09.2024.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research (ISSN 1438-8871), is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.
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