Meta-Analysis Methodology for Basic Research: A Practical Guide
Meta-Analysis Methodology for Basic Research: A Practical Guide
1 What is meta-analysis?
A practical Guide to do Primary research on Meta analysis Methodology
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Statistical Procedure in Meta-Essentials
Meta Analysis Research Methodology #research
Statistical Power of a Meta-Analysis
Meta Analysis Research (मेटा विश्लेषण अनुसंधान) #ugcnet #ResearchMethodology #educationalbyarun
What is a Meta-Analysis?
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Meta-Analysis
Definition. "A meta-analysis is a formal, epidemiological, quantitative study design that uses statistical methods to generalise the findings of the selected independent studies. Meta-analysis and systematic review are the two most authentic strategies in research. When researchers start looking for the best available evidence concerning ...
How to conduct a meta-analysis in eight steps: a practical guide
2.1 Step 1: defining the research question. The first step in conducting a meta-analysis, as with any other empirical study, is the definition of the research question. Most importantly, the research question determines the realm of constructs to be considered or the type of interventions whose effects shall be analyzed.
Introduction to systematic review and meta-analysis
It is easy to confuse systematic reviews and meta-analyses. A systematic review is an objective, reproducible method to find answers to a certain research question, by collecting all available studies related to that question and reviewing and analyzing their results. A meta-analysis differs from a systematic review in that it uses statistical ...
Meta-analysis
Graphical summary of a meta-analysis of over 1,000 cases of diffuse intrinsic pontine glioma and other pediatric gliomas, in which information about the mutations involved as well as generic outcomes were distilled from the underlying primary literature. Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.
Meta-analysis
Meta-analysis is an objective examination of published data from many studies of the same research topic identified through a literature search. Through the use of rigorous statistical methods, it ...
Meta-Analytic Methodology for Basic Research: A Practical Guide
The goal of this study is to present a brief theoretical foundation, computational resources and workflow outline along with a working example for performing systematic or rapid reviews of basic research followed by meta-analysis. Conventional meta-analytic techniques are extended to accommodate methods and practices found in basic research.
Research Guides: Study Design 101: Meta-Analysis
Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
Meta-Analysis: A Quantitative Approach to Research Integration
Additional statistical research should include study of the impact of outliers on the meta-analysis and the potential insight that they could provide into a research question . Statistically valid methods to combine data across studies of varying quality and design, including data from case-control studies, will enable metaanalysts to maximize ...
Methods
Meta-analysis is a method for summarizing the statistical findings from a research literature. For example, if five experiments have been conducted using the same intervention and outcome measure on the same population of people with five separate estimates of an average treatment effect, one might imagine pooling these five studies together ...
Meta-analysis: Principles and procedures
Meta-analysis is a statistical procedure that integrates the results of several independent studies considered to be "combinable."1 Well conducted meta-analyses allow a more objective appraisal of the evidence than traditional narrative reviews, provide a more precise estimate of a treatment effect, and may explain heterogeneity between the results of individual studies.2 Ill conducted ...
What is Meta-Analysis? Definition, Research & Examples
Meta-analysis is a quantitative research method that involves the systematic synthesis and statistical analysis of data from multiple individual studies on a particular topic or research question. It aims to provide a comprehensive and robust summary of existing evidence by pooling the results of these studies, often leading to more precise and ...
Getting Started
A systematic review may include a meta-analysis. For details about carrying out systematic reviews, see the Guides and Standards section of this guide. Is my research topic appropriate for systematic review methods? A systematic review is best deployed to test a specific hypothesis about a healthcare or public health intervention or exposure.
What is a Meta-Analysis?
A meta-analysis is defined by Haidlich (2010) as "a quantitative, formal, epidemiological study design used to systematically assess previous research studies to derive conclusions about that body of research. Outcomes from a meta-analysis may include a more precise estimate of the effect of treatment or risk factor for disease, or other outcomes, than any individual study contributing to the ...
How to conduct a qualitative meta-analysis: Tailoring methods ...
Rather than arguing for the adoption of any single meta-method, this paper advocates for considering how procedures can best be selected and adapted to enhance a meta-study's methodological integrity. Method: Through the paper, recommendations are provided to help researchers identify procedures that can best serve their studies' specific goals.
Meta-analysis: What, Why, and How
Meta-analyses play a fundamental role in evidence-based healthcare. Compared to other study designs (such as randomized controlled trials or cohort studies), the meta-analysis comes in at the top of the evidence-based medicine pyramid. This is a pyramid which enables us to weigh up the different levels of evidence available to us.
Introduction to meta-analysis
This text provides a concise and clearly presented discussion of all the elements in a meta-analysis. It is illustrated with worked examples throughout, with visual explanations, using screenshots from Excel spreadsheets and computer programs such as Comprehensive Meta-Analysis (CMA) or Strata.
The Sydney system for lymph node FNA biopsy cytopathology: A detailed
The meta-analysis was then incorporated into this study to provide ranges and pooled outcomes. The meta-analysis did not include one of the 10 studies reviewed. 9 One of the crucial steps in a meta-analysis is to decide which studies to include, and there is no information in the meta-analysis why this Torres Rivas et al. 9 study was excluded ...
A systematic review and meta-analysis of strategies to promote ...
Liu et al. present a systematic review and meta-analysis of 88 randomized controlled trials testing the effectiveness of seven intervention strategies for increasing vaccination uptake.
The Complex Pattern Mismatch Negativity as a Potential ...
A meta-analysis using the random effects and inverse-variance weighting method was performed utilizing the R meta package (R Core Team. R: A Language and Environment for Statistical Computing. 2023 ... Sage Research Methods Supercharging research opens in new tab; Sage Video Streaming knowledge opens in new tab; Technology from Sage Library ...
EQ-5D Based Utility Values for Adults with Chronic Obstructive
For the method of elicitation (EQ-5D-3L vs. EQ-5D-5L), disease stage, and region subgroups, it was found that the moderators in each subgroup had a statistically significant impact on the effect sizes in the meta-analysis. In other words, whether the method of elicitation was EQ-5D-3L or EQ-5D-5L is associated with the differences in utility ...
Findings of meta-analysis confirm MDA for STH is cost-effective
In this meta-analysis, we reaffirm significant positive health impacts of MDA and show that it is cost-effective. The WHO recommends mass drug administration (MDA) for intestinal worm infections in areas with over 20% infection prevalence. Recent Cochrane meta-analyses endorse treatment of infected individuals but recommend against MDA.
Meta-Analysis
Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
Combination therapy of acupuncture and herbal medicine for ...
Treatment safety was evaluated based on the incidence of AEs. The methodological quality of all included RCTs was assessed using the Cochrane risk of bias tool. A meta-analysis was performed using Review Manager, version 5.4.1. Results: Of the 133 publications identified, 8 RCTs met the inclusion criteria. The meta-analysis showed significant ...
Prophylactic tranexamic acid for reducing blood loss in pregnant
This analysis showed a consistent benefit of TXA by reducing the log odds ratio of blood transfusion by −0.77 (−1.33, −0.22). The forest plot of this meta-analysis is shown in Figure 12. One study 21 recorded zero transfusions in either group, this was incorporated into the analysis using Peto's method.
IMAGES
VIDEO
COMMENTS
Definition. "A meta-analysis is a formal, epidemiological, quantitative study design that uses statistical methods to generalise the findings of the selected independent studies. Meta-analysis and systematic review are the two most authentic strategies in research. When researchers start looking for the best available evidence concerning ...
2.1 Step 1: defining the research question. The first step in conducting a meta-analysis, as with any other empirical study, is the definition of the research question. Most importantly, the research question determines the realm of constructs to be considered or the type of interventions whose effects shall be analyzed.
It is easy to confuse systematic reviews and meta-analyses. A systematic review is an objective, reproducible method to find answers to a certain research question, by collecting all available studies related to that question and reviewing and analyzing their results. A meta-analysis differs from a systematic review in that it uses statistical ...
Graphical summary of a meta-analysis of over 1,000 cases of diffuse intrinsic pontine glioma and other pediatric gliomas, in which information about the mutations involved as well as generic outcomes were distilled from the underlying primary literature. Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.
Meta-analysis is an objective examination of published data from many studies of the same research topic identified through a literature search. Through the use of rigorous statistical methods, it ...
The goal of this study is to present a brief theoretical foundation, computational resources and workflow outline along with a working example for performing systematic or rapid reviews of basic research followed by meta-analysis. Conventional meta-analytic techniques are extended to accommodate methods and practices found in basic research.
Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
Additional statistical research should include study of the impact of outliers on the meta-analysis and the potential insight that they could provide into a research question . Statistically valid methods to combine data across studies of varying quality and design, including data from case-control studies, will enable metaanalysts to maximize ...
Meta-analysis is a method for summarizing the statistical findings from a research literature. For example, if five experiments have been conducted using the same intervention and outcome measure on the same population of people with five separate estimates of an average treatment effect, one might imagine pooling these five studies together ...
Meta-analysis is a statistical procedure that integrates the results of several independent studies considered to be "combinable."1 Well conducted meta-analyses allow a more objective appraisal of the evidence than traditional narrative reviews, provide a more precise estimate of a treatment effect, and may explain heterogeneity between the results of individual studies.2 Ill conducted ...
Meta-analysis is a quantitative research method that involves the systematic synthesis and statistical analysis of data from multiple individual studies on a particular topic or research question. It aims to provide a comprehensive and robust summary of existing evidence by pooling the results of these studies, often leading to more precise and ...
A systematic review may include a meta-analysis. For details about carrying out systematic reviews, see the Guides and Standards section of this guide. Is my research topic appropriate for systematic review methods? A systematic review is best deployed to test a specific hypothesis about a healthcare or public health intervention or exposure.
A meta-analysis is defined by Haidlich (2010) as "a quantitative, formal, epidemiological study design used to systematically assess previous research studies to derive conclusions about that body of research. Outcomes from a meta-analysis may include a more precise estimate of the effect of treatment or risk factor for disease, or other outcomes, than any individual study contributing to the ...
Rather than arguing for the adoption of any single meta-method, this paper advocates for considering how procedures can best be selected and adapted to enhance a meta-study's methodological integrity. Method: Through the paper, recommendations are provided to help researchers identify procedures that can best serve their studies' specific goals.
Meta-analyses play a fundamental role in evidence-based healthcare. Compared to other study designs (such as randomized controlled trials or cohort studies), the meta-analysis comes in at the top of the evidence-based medicine pyramid. This is a pyramid which enables us to weigh up the different levels of evidence available to us.
This text provides a concise and clearly presented discussion of all the elements in a meta-analysis. It is illustrated with worked examples throughout, with visual explanations, using screenshots from Excel spreadsheets and computer programs such as Comprehensive Meta-Analysis (CMA) or Strata.
The meta-analysis was then incorporated into this study to provide ranges and pooled outcomes. The meta-analysis did not include one of the 10 studies reviewed. 9 One of the crucial steps in a meta-analysis is to decide which studies to include, and there is no information in the meta-analysis why this Torres Rivas et al. 9 study was excluded ...
Liu et al. present a systematic review and meta-analysis of 88 randomized controlled trials testing the effectiveness of seven intervention strategies for increasing vaccination uptake.
A meta-analysis using the random effects and inverse-variance weighting method was performed utilizing the R meta package (R Core Team. R: A Language and Environment for Statistical Computing. 2023 ... Sage Research Methods Supercharging research opens in new tab; Sage Video Streaming knowledge opens in new tab; Technology from Sage Library ...
For the method of elicitation (EQ-5D-3L vs. EQ-5D-5L), disease stage, and region subgroups, it was found that the moderators in each subgroup had a statistically significant impact on the effect sizes in the meta-analysis. In other words, whether the method of elicitation was EQ-5D-3L or EQ-5D-5L is associated with the differences in utility ...
In this meta-analysis, we reaffirm significant positive health impacts of MDA and show that it is cost-effective. The WHO recommends mass drug administration (MDA) for intestinal worm infections in areas with over 20% infection prevalence. Recent Cochrane meta-analyses endorse treatment of infected individuals but recommend against MDA.
Meta-analysis would be used for the following purposes: To establish statistical significance with studies that have conflicting results. To develop a more correct estimate of effect magnitude. To provide a more complex analysis of harms, safety data, and benefits. To examine subgroups with individual numbers that are not statistically significant.
Treatment safety was evaluated based on the incidence of AEs. The methodological quality of all included RCTs was assessed using the Cochrane risk of bias tool. A meta-analysis was performed using Review Manager, version 5.4.1. Results: Of the 133 publications identified, 8 RCTs met the inclusion criteria. The meta-analysis showed significant ...
This analysis showed a consistent benefit of TXA by reducing the log odds ratio of blood transfusion by −0.77 (−1.33, −0.22). The forest plot of this meta-analysis is shown in Figure 12. One study 21 recorded zero transfusions in either group, this was incorporated into the analysis using Peto's method.