biomolecular nmr assignments

Biomolecular NMR Assignments is a dedicated forum for publishing sequence-specific resonance assignments for proteins and nucleic acids. Provides an avenue for depositing these data into a public database at BioMagResBank.

Backbone and sidechain NMR assignments of residues 1–81 from yeast Sis1 in complex with an Hsp70 C-terminal EEVD peptide. Biomolecular NMR Assignments is a dedicated forum for publishing sequence-specific resonance assignments for proteins and nucleic acids. Provides an avenue ...

Biomolecular NMR Assignments provides a forum for publishing sequence-specific resonance assignments for proteins and nucleic acids as Assignment Notes. Chemical shifts for NMR-active nuclei in macromolecules contain detailed information on molecular conformation and properties.

We here report the near-complete NMR backbone chemical shifts of the putative Nsp3e NAB that reveal the secondary structure and compactness of the domain, and provide a basis for NMR-based investigations towards understanding and interfering with RNA- and small-molecule-binding by Nsp3e.

Here, we report the backbone and side chain NMR resonance chemical shift assignments and provide an initial chemical-shift-based secondary structure analysis of the hitherto structurally “unknown” human protein DBNDD1.

Here, we describe an NMR assignment activity aimed at advanced undergraduate or graduate level students in either the biological or chemical sciences. Using a variety of NMR spectral data, students assigned the protons of the horse cytochrome c heme cofactor in a single 4 h session.

These NMR assignments will serve as a useful tool in the discovery of small-molecule therapeutics targeting PD-L1 and in the characterisation of functional interactions with other protein...

The beautiful review by Reif describes the versatile use of deuteration and proton detection for high-resolution MAS NMR spectroscopy of biological systems, including labeling strategies and experimental approaches for resonance assignments and quantitative characterization of structure and dynamics.

The fundamental data produced by biomolecular NMR spectroscopy are multidimensional NMR spectra. All NMR-based information is derived from these spectra, generally by chemical shift...

We describe selected recent examples of how solution NMR can provide unique insights into protein function that are unachievable by other structural methods, and how biomolecular NMR itself will benefit from the AI-enhanced era of structural biology.